In this study, a robust H_2/H_∞ multi-objective state-feedback controller and tracking design are presented for a mobile two-wheeled inverted pendulum (MTWIP). The proposed control has to track the desired angular velocity while keeping the mobile two-wheeled inverted pendulum balanced. First, error of output states are added to the dynamic of system for better tracking control. And uncertainties of parameters are defined by affine parameters. Next, Takagi-Sugeno (T-S) fuzzy model is used for estimating the uncertainty of nonlinear model parameters. Robust H_2/H_∞ controller is designed and analyzed for each local linear subsystem of mobile two-wheeled inverted pendulum by using a linear matrix inequalities method. To sum up, in order to calculate the whole dynamic of system from each local linear subsystem, weight average defuzzifer method is used and the total controller is designed and analyzed according to parallel distribute compensation. The simulation indicate that the proposed scheme has high accuracy, robustness, good tracking, fast transient responses and lower control effort for a mobile two-wheeled inverted pendulum despite the uncertainties and external disturbance.